Study Indicates That Childhood Cancer Survivors Have a Genetic Risk for Future Cancers

An abstract presentation April 3, 2017 at the American Association for Cancer Research (AACR) 2017 Annual Meeting (Abstract 3001) reports on a study of 3007 childhood cancer survivors enrolled in the St. Jude's Lifetime Cohort study.  Whole-genome sequencing study in this patient population found almost 12% of childhood cancer survivors have genetic mutations that put them – or their children – at risk for future cancers. This study contributes to an improved understanding of why survivors may be at increased risk for a subsequent new cancer.